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MouseAnti-CRP antibody (V0102)
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100ug/1880.00元
200ug/2980.00元
大包装/询价
产品编号 V0102
英文名称 CRP
中文名称 C-反应蛋白单克隆抗体
别    名 C-reactive protein; C Reactive Protein; C reactive protein pentraxin related; CRP; MGC88244; PTX 1; PTX1.  C反应蛋白
研究领域 心血管  免疫学  信号转导  细胞凋亡  生长因子和激素  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 5D12
交叉反应 (predicted: Human, )
产品应用 ELISA=1:5000-10000 ICA=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 25kDa
细胞定位 分泌型蛋白 
性    状 Liquid
免 疫 原 Human CRP protein 
亚    型 IgG2b
纯化方法 affinity purified by Protein G
缓 冲 液 0.01M PBS(pH7.4)
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.

Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Subunit:
Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular Location:
Secreted.

Tissue Specificity:
Found in plasma.

Similarity:
Belongs to the pentaxin family.
Contains 1 pentaxin domain.

SWISS:
P02741

Gene ID:
1401

Database links:

Entrez Gene: 1401 Human

Omim: 123260 Human

SwissProt: P02741 Human

Unigene: 76452 Human



C反应蛋白 CRP(C-reactive protin)是与C性肺炎球菌的多糖起反应的一种蛋白,在某些细菌的感染过程中出现在血浆中。
CRP是在一些病理性情况下出现于病人血清中的一种糖蛋白,特别是在伴有肯炎症和组织坏死疾病的急性期。血清中出现的这种异常蛋白能和肺炎C-多糖体发生沉淀反应,当疾病好转或缓解时,CRP减低或消失。
临床意义:
(1)各种急性化脓性炎症、菌血症、组织坏死(心肌梗塞、手术、严重创伤、烧伤等)、恶性肿瘤、结缔组织病、肾移殖后急性排异反应、急性风湿热、风湿性关节炎、类风湿性关节炎、心肌炎急性期、肺炎、肺结核、系统性红斑狼疮、急性肝炎和阑尾炎等,血清中CRP含量可增高,它的出现比其它急性期的反应物质早,所以对疾病的早期诊断很有帮助。
CRP可以鉴别细菌炎症或者是病毒性炎症。细菌性炎症CRP可以明显增高,而病毒性炎症CRP的血清含量一般都在正常范围。
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