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Rabbit Anti-MMP9 antibody (bs-4593R)
~~~促销,代码SSY221101~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
技术支持:techsupport@bioss.com.cn
说明书: 50ul  100ul  200ul
50ul/1098.00元
100ul/1880.00元
200ul/2900.00元
大包装/询价
产品编号 bs-4593R
英文名称 MMP9
中文名称 基质金属蛋白酶9抗体
别    名 Matrix metalloproteinase-9 precursor; MMP-9; MMP9; MMP 9; 92 kDa type IV; Collagenase; 92 kDa gelatinase; Gelatinase B; GELB; MMP9_HUMAN; 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG-4B; CLG4B; Collagenase Type 4 beta; Collagenase Type-4 beta; Collagenase type IV 92 KD; Collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase 92 KD; Gelatinase beta; Gelatinase-beta; GelatinaseB; GELB; Macrophage gelatinase; MANDP2; Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix Metalloproteinase 9; Type V collagenase.  
Specific References  (45)     |     bs-4593R has been referenced in 45 publications.
[IF=2.37] Wenchong Sun. et al. Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Exp Neurobiol. 2020 Oct 31; 29(5): 356–375  WB,IF ;  Rat.  
[IF=4.603] Yaginuma Tatsuki. et al. p130Cas induces bone invasion by oral squamous cell carcinoma by regulating tumor epithelial–mesenchymal transition and cell proliferation. Carcinogenesis. 2020 Aug;41(8):1038-1048  IHC ;  Mouse.  
[IF=4.175] Jia Guo. et al. Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p. Cancer Cell Int. 2020 Dec;20(1):1-12  WB ;  Human.  
[IF=2.886] Jiancong Lu. et al. Circ_0020123 Increases ZFX Expression to Facilitate Non-Small Cell Lung Cancer Progression by Sponging miR-142-3p. Cancer Manag Res. 2021; 13: 1687–1698  WB ;  Human.  
[IF=4.225] Jiang Q et al. Particulate Matter 2.5 Induced Developmental Cardiotoxicity in Chicken Embryo and Hatchling. Front Pharmacol. 2020 Jun 5;11:841.  WB ;  Chicken.  
[IF=3.072] Xue Y et al. miR‐205‐5p inhibits psoriasis‐associated proliferation and angiogenesis: Wnt/β‐catenin and mitogen‐activated protein kinase signaling pathway are involved. J Dermatol . 2020 Aug;47(8):882-892.  WB ;  Mouse&Human.  
[IF=5.572] Liu H et al. Anti-tubulin agent vinorelbine inhibits metastasis of cancer cells by regulating epithelial-mesenchymal transition. Eur J Med Chem. 2020 Aug 15;200:112332.  WB ;  Human.  
[IF=4.966] Bianchetto-Aguilera F et al. Deciphering the fate of slan+‐monocytes in Human tonsils by gene expression profiling. FASEB J. 2020 Jul;34(7):9269-9284.  IHC ;  Human.  
[IF=3.174] Xiaole Tong et al. LPS-induced inflammation disorders bone modeling and remodeling by inhibiting angiogenesis and disordering osteogenesis in chickens. Inflamm Res. 2020 Aug;69(8):765-777.  WB ;  Chicken.  
[IF=1.646] Wang C et al. Effect of MicroRNA-126a-3p on Bone Marrow Mesenchymal Stem Cells Repairing Blood-brain Barrier and Nerve Injury after Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2020 May;29(5):104748.  WB ;  rat.  
[IF=3.775] Chen Z et al. Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice. Food Chem Toxicol. 2019 Aug;130:1-11.  WB ;  Human.  
[IF=1.466] Yan B et al. Suppression of puerarin on polymethylmethacrylate-induced lesion of peri-implant by inhibiting NF-κB activation in vitro and in vivo.Pathol Res Pract. 2019 Mar 1:152372.  WB ;  Mouse.  
[IF=3.457] Li W et al. Upregulation of MMP-9 and CaMKII prompts cardiac electrophysiological changes that predispose denervated transplanted hearts to arrhythmogenesis after prolonged cold ischemic storage. Biomed Pharmacother. 2019 Feb 20;112:108641.  WB ;  Rat.  
[IF=1.68] Wang et al. The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment. (2017) J.Ophthalmol. 2017:6067891  IHC ;  Rabbit.  
[IF=3.457] Chai FN et al. Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.Biomed Pharmacother. 2018 Jul;103:1002-1011.  WB ;  Mouse.  
[IF=1.39] He et al. Long non-coding RNA SPRY4-IT1 promotes the proliferation and invasion of U251 cells through upregulation of SKA2. (2018) Oncol.Lett. 15:3977-3984  WB ;  Human.  
[IF=2.11] Lee et al. Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-κB signaling pathways. (2017) Mol.Vi. 22:1490-1502  WB ;  Human.  
[IF=4.26] Parveen et al. Unconventional MAPK-GSK-3β Pathway Behind Atypical Epithelial-Mesenchymal Transition In Hepatocellular Carcinoma. (2017) Sci.Re. 7:8842  WB ;  Human.  
[IF=3.14] Varghese, Sheeja, et al. "The inhibitory effect of anti-tumor polysaccharide from Punica granatum on metastasis." International Journal of Biological Macromolecules (2017).  WB ;  Human.  
[IF=1.712] Wang, Menglei, et al. "The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment." Journal of Ophthalmology 2017 (2017).  IHC-P ;  Rabbit.  
[IF=1.55] Yang, Jinjiang, Ying Lu, and Ai Guo. "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." Molecular Medicine Reports 14.5 (2016): 4075-4082.  WB ;  Rat.  
[IF=5.168] Yu, Chengyuan, et al. "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." Oncotarget 8.23 (2017): 37705.  WB, IHC-P ;  Dog.  
[IF=5.646] Ye T et al. MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer. J Exp Clin Cancer Res. 2019 Feb 6;38(1):55.  FCM&IHC ;  Mouse&Human.  
[IF=3.386] Wen-chong Sun. et al. Dexmedetomidine attenuates propofol-induced apoptosis of neonatal hippocampal astrocytes by inhibiting the Bcl2l1 signaling pathway. 2021 Nov 04  WB,IF ;  Rat.  
[IF=2.94] Deng, XiaHeng, et al. "MiR-21 involve in ERK-mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia." Brain Research Bulletin (2013).  WB ;  Rat.  
[IF=2.466] Jinjiang Yang. et al. Platelet-rich plasma attenuates interleukin-1β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α. Tissue Cell. 2021 Sep;:101646  WB ;  rat.  
[IF=2.754] Wu, Guoxian. et al. Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12. World J Surg Oncol. 2021 Dec;19(1):1-12  WB ;  Human.  
[IF=4.932] Qingyu Meng. et al. Morin hydrate inhibits atherosclerosis and LPS-induced endothelial cells inflammatory responses by modulating the NFκB signaling-mediated autophagy. Int Immunopharmacol. 2021 Nov;100:108096  WB ;  Human.  
[IF=1.837] Yang Zhang. et al. Plumbagin Inhibits Proliferation, Migration, and Invasion of Retinal Pigment Epithelial Cells Induced by FGF-2. Tissue Cell. 2021 Oct;72:101547  WB ;  Human.  
[IF=4.848] Chen Chenglong. et al. miR-135a Reduces Osteosarcoma Pulmonary Metastasis by Targeting Both BMI1 and KLF4. Front Oncol. 2021 Mar;11:930  IF ;  Human.  
[IF=5.328] Jing Shen. et al. Distribution and Dynamic Changes in Matrix Metalloproteinase (MMP)-2, MMP-9, and Collagen in an In Stent Restenosis Process. Eur J Vasc Endovasc. 2021 Jan;:  WB,IHC ;  Pig.  
[IF=3.707] He Meng. et al. Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain. Front Neurosci-Switz. 2021 Jan;14:1398  WB ;  Human, Rat.  
[IF=2.886] Yunqi Hua. et al. Circular RNA Circ_0006282 Promotes Cell Proliferation and Metastasis in Gastric Cancer by Regulating MicroRNA-144-5p/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein β Axis. Cancer Manag Res. 2021; 13: 815–827  WB ;  Human.  
[IF=4.004] Yaginuma T et al. p130Cas induces bone invasion by oral squamous cell carcinoma by regulating tumor epithelial-mesenchymal transition and cell proliferation. Carcinogenesis. 2020 Jan 30. pii: bgaa007.  IHC-P ;  Mouse.  
[IF=3.361] Varghese S et al. Immunostimulatory plant polysaccharides impede cancer progression and metastasis by avoiding off-target effects. Int Immunopharmacol. 2019 May 21;73:280-292.  WB ;  Human.  
[IF=4.776] Ma F et al. In situ fabrication of a composite hydrogel with tunable mechanical properties for cartilage tissue engineering. J. Mater. Chem. B, 2019.  WB ;  Human.  
[IF=2.25] Fan S et al.Carboxypeptidase E-ΔN promotes migration, invasion and epithelial-mesenchymal transition of human osteosarcoma cell lines through the Wnt/β-catenin pathway.(2018) Biochem Cell Biol.  WB ;  Human.  
[IF=2.25] Shi S et al. MicroRNA-34a attenuates VEGF-mediated retinal angiogenesis via targeting the Notch1.(2018) Biochemistry and Cell Biology  WB ;  Rat &Human.  
[IF=2.25] Yang X et al.Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration and invasion, and promotes apoptosis in pancreatic cancer cells. (2018)Biochem. Cell Biol.  WB ;  Human.  
[IF=2.976] Chen X et al. Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells.(2019)Oncol Rep. Feb;41(2):765-778.  WB ;  
[IF=3.457] Gungor H et al. The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer. Biomed Pharmacother. 2018 Jun;102:221-229.  IHC-P ;  Rat.  
[IF=2.54] Wang, Li, et al. "Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model." Peptides (2017).  IHC-P ;  Rabbit.  
[IF=1.43] Wang, Xiao-yan, et al. "AMD3100 attenuates MMP-3 and MMP-9 expressions and prevents cartilage degradation in a monosodium iodoacetate-induced rat model of temporomandibular osteoarthritis." Journal of Oral and Maxillofacial Surgery (2016).  IHC-P ;  Rat.  
[IF=1.93] Lee, Hye Sook, et al. "Anti-neovascular effect of chondrocyte-derived extracellular matrix on corneal alkaline burns in rabbits." Graefes Archive for Clinical and Experimental Ophthalmology (2014): 1-11.  IHC-P ;  Rabbit.  
[IF=2.52] Liu, Tianbo, et al. "Correlation of TNFAIP8 overexpression with the proliferation, metastasis, and disease-free survival in endometrial cancer." Tumor Biology (2014): 1-10.  IHC-P ;  Human.  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  信号转导  转录调节因子  合成与降解  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Dog,  (predicted: Mouse, Rat, Chicken, Pig, Horse, Rabbit, Sheep, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 78kDa
细胞定位 细胞外基质 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMP9: 151-250/707 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn(2+) binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.

Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Subunit:
Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.

Subcellular Location:
Secreted, extracellular space, extracellular

Tissue Specificity:
Produced by normal alveolar macrophages and granulocytes.

Post-translational modifications:
Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
N- and O-glycosylated.

DISEASE:
Defects in MMP9 may be a cause of susceptibility to intervertebral disc disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.
Defects in MMP9 are the cause of metaphyseal anadysplasia type 2 (MANDP2) [MIM:613073]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.

Similarity:
Belongs to the peptidase M10A family.

SWISS:
P14780

Gene ID:
4318

Database links:

Entrez Gene: 403885 Dog

Entrez Gene: 4318 Human

Entrez Gene: 17395 Mouse

Entrez Gene: 81687 Rat

Omim: 120361 Human

SwissProt: O18733 Dog

SwissProt: P14780 Human

SwissProt: P41245 Mouse

SwissProt: P50282 Rat

Unigene: 297413 Human

Unigene: 4406 Mouse

Unigene: 10209 Rat




MMP9亦称IV型胶原酶或明胶酶B,其主要功能为降解IV型胶原。因而它在肿瘤细胞突破基底膜屏障和浸润转移中起重要作用。目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与转移浸润的研究。细胞外基质在维持正常组织结构与功能以及细胞生长和分化过程中起重要作用。细胞外基质动态平衡的失调与肿瘤细胞侵袭、转移和复发密切相关,基质金属蛋白酶(MMP9)是细胞外基质的降解酶,可降解Ⅳ、Ⅴ、Ⅸ、Ⅺ型胶原,在肿瘤的浸润、转移过程中起重要作用,近年为肿瘤研究的热点。
盐酸强力霉素还是多种基质金属蛋白酶(MMPs)的抑制剂,包括MMP-8(neutrophil collagenase; IC50 =30 μM)和MMP-1(interstitial collagenase; IC50 = 300 µM)。研究报道,复发性角膜糜烂研究中它能够显著降低MMP-9的表达水平和活性。
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