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Rabbit Anti-HIF1 beta antibody (bs-1407R)
~~~促销,代码SSY221101~~~
订购热线:400-901-9800
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说明书: 50ul  100ul  200ul
50ul/1138.00元
100ul/1880.00元
200ul/2900.00元
大包装/询价

产品编号 bs-1407R
英文名称 HIF1 beta
中文名称 缺氧诱导因子1β/HIF-1β抗体
别    名 HIF1 beta; ARNT1; ARNT; HIF 1 beta; HIF-1 Beta; ARNT protein; Aryl Hydrocarbon Receptor Nuclear Translocator ; Dioxin Receptor; Dioxin receptor nuclear translocator; Drnt; HIF 1 beta;HIF 1beta; HIF1B; HIF1beta; Hypoxia Inducible Factor 1; Hypoxia inducible factor 1 beta; Tango; ARNT_HUMAN; Class E basic helix-loop-helix protein 2; bHLHe2; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; HIF-1 β; HIF1-β; HIF 1-β; HIF-1-β; HIF 1 β; HIF1β; HIF1 β; HIF1-β; HIF 1β.  
研究领域 肿瘤  心血管  染色质和核信号  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 87kDa
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HIF-1 Beta: 681-789/789 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Function:
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.

SWISS:
P27540

Gene ID:
405

Database links:

Entrez Gene: 405 Human

Entrez Gene: 11863 Mouse

Entrez Gene: 25242 Rat

Omim: 126110 Human

SwissProt: P27540 Human

SwissProt: P53762 Mouse

SwissProt: P41739 Rat

Unigene: 632446 Human

Unigene: 250265 Mouse

Unigene: 10520 Rat



转录调节因子(Transcriptin Regulators)
低氧诱导因子1β不仅对于机体在缺氧条件下维持正常的生理功能具有特别重要的意义,并在肿瘤的生长以及神经细胞凋亡等病理过程中起重要作用. HIF1β又称芳烃受体核转运蛋白1能调节许多下游基因的表达水平.
哺乳动物细胞在低氧压力条件下出现HIF。HIF是一种转录因子,对细胞的缺氧起稳定作用。
产品图片
Paraformaldehyde-fixed, paraffin embedded (Mouse uterus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HIF1 beta) Polyclonal Antibody, Unconjugated (bs-1407R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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