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RabbitAnti-IL13 antibody (bs-0560R)
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说明书: 50ul  100ul  200ul
50ul/1098.00元
100ul/1880.00元
200ul/2900.00元
大包装/询价

产品编号 bs-0560R
英文名称 IL13
中文名称 白介素13抗体
别    名 Interleukin-13; Interleukin 13; Interleukin13; ALRH; BHR 1; BHR1; IL 13; IL-13; MGC116786; MGC116788; MGC116789; NC30; P600; Interleukin-13; T-cell activation protein P600; IL13_MOUSE; IL13_HUMAN.  
Specific References  (5)     |     bs-0560R has been referenced in 5 publications.
[IF=1.785] Ying Xue. et al. Application of TGF‑β1, TIMP‑1 and TIMP‑2 small interfering RNAs can alleviate CCl4‑induced hepatic fibrosis in rats by rebalancing Th1/Th2 cytokines. Exp Ther Med. 2021 Sep;22(3):1-7  WB,IHC ;  Rat.  
[IF=9.038] Bin Li. et al. lncRNA TUG1 as a ceRNA promotes PM exposure-induced airway hyper-reactivity. J Hazard Mater. 2021 Aug;416:125878  WB ;  Mouse.  
[IF=1.55] Yang, Lijuan, et al. "Effect of IL-17 in the development of colon cancer in mice." Oncology Letters 12.6 (2016): 4929-4936.  WB ;  Mouse.  
[IF=5.249] Liang, Wei. et al. Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment. 2021 Sep 27  WB ;  Rat.  
[IF=3.115] Jing L et al. Srolo Bzhtang, a traditional Tibetan medicine formula, inhibits cigarette smoke induced airway inflammation and muc5ac hypersecretion via suppressing IL-13/STAT6 signaling pathway in rats. J Ethnopharmacol. 2019 May 10;235:424-434.  IHC-P&WB ;  Rat.  
研究领域 肿瘤  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Sheep, )
产品应用 WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 12kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-13: 45-56/131(mo) 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]


Function:
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subcellular Location:
Secreted.

DISEASE:
Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Similarity:
Belongs to the IL-4/IL-13 family.

SWISS:
P20109

Gene ID:
16163

Database links:

Entrez Gene: 3596 Human

Entrez Gene: 16163 Mouse

Entrez Gene: 116553 Rat

Omim: 147683 Human

SwissProt: P35225 Human

SwissProt: P20109 Mouse

SwissProt: P42203 Rat

Unigene: 845 Human

Unigene: 1284 Mouse

Unigene: 9921 Rat



产品图片
Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-13) Polyclonal Antibody, Unconjugated (bs-0560R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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